There are several WF in SF and I think this one is the smallest. It has a good selection, but the baskets are the mini kind, aisles are narrow and the parking lot is highly competitive. My tips: If you come during off-hours, check the small lot at street level with an entrance off Franklin first. If it's full, go around to the underground parking entrance off California to try to find a spot. If you come during busy times, don't even try circling and squeezing your car into the most compact of compact spaces. Just find street parking on the nearby residential blocks.
It's rather crowded and chaotic inside but for sure cheerful, with helpful employees. They have the usual WF selection, including a vitamin/personal care section, ingredients for many ethnic foods, and organic and healthful versions of most things. Vegan faux meats and dairy products abound, along with an impressive section of produce flown in from around the world. There's also a small garden/flowers section by the Franklin side entrance, and a cafe downstairs at the California doors. Their bakery section's vegan chocolate-raspberry cake has saved a birthday more than once! :)
Grab the paper "Whole Deal" booklet at the top of the stairs on the way in and you just might find coupons for $ off some items.
Like many CA grocery stores they offer beer and wine but not hard liquor here. Fortunately, BevMo is your place for the best variety of adult drink supplies and it's only 3 blocks away.
Cons: Expensive (of course, it's WF!), Parking lot normally full